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HotSpot Detection


Introduction

Apostle MiniEnrich HotSpot Panel (v1.0) targets the“hotspot" regions of tumor mutation, involving 49 genes related to carcinogenesis and tumor suppressor, with probes covering approximately 25 Kb of the genome.

    This Panel is designed for use with the Apostle MiniEnrich Hybrid Capture System. Based on the novel Apostle MiniEnrich targeted enrichment system, the Apostle MiniEnrich HotSpot Panel (v1.0) delivers improved capture efficiency, consistent and excellent capture performance, and significantly reduces experimental time, enabling more efficient sequencing and cost savings.


  • Gene list

Performance

Capture performance

Variant analysis
A new clinical study, led by scientists from MD Anderson Cancer Center and published in Cancer Cell (journal impact factor = 50.3), shows that tumor and cfDNA methylation can be used to identify SCLC subtypes and might guide precision SCLC therapy. Apostle MiniMax cfDNA kit is one of the critical commercial assays listed in this article. Congratulations to this clinical research team. To date, the Apostle MiniMax technology has been used in 2 articles published in Nature Communications, 2 in Nature Medicine, 1 in Science Translational Medicine, 1 in PNAS, and over 60 scientific articles by over 60 international research and clinical teams in different journals.