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Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S)

Designed for small DNA fragments (<100 bp) 

For research use only. Not for use in diagnostic procedures.

Overview, Apostle MiniMax (Type S)

Powered by Apostle MiniMax technology, Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) is an excellent tool for the isolation of ultra-low concentration cell free DNA (cfDNA). Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) is featured for its efficient recovery of small DNA fragments ( <100 bp) from biological samples, where major alternative products fail. This feature is quite useful when small DNA molecules have significant presence in the biological sample and need to be isolated.


ProductsCat #Protocol
Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) (25-50 preps)
A17830-50
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Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) (5-10 preps)
A17830-10
Download Protocol


Performance Data

Compared to major alternative suppliers with magnetic bead technology, Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) offers superior DNA isolation efficiency for cfDNA reference spiked in biological medium, especially for cfDNA with size <80 bp (Exhibit 1-3).

Exhibit 1. Superior small DNA isolation efficiency.

A) cfDNA reference standard (Horizon Discovery Ltd, Cat# HD780) was spiked in TE buffer, followed by isolation with Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S). The isolated DNA was characterized by Bioanalyzer 2100 (red curve), and compared with original cfDNA reference standard (blue curve). Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) offers >95% recovery of the cfDNA reference standard, which has significant portion of DNA fragments with size <100 bp.

Exhibit 2. Superior small DNA isolation efficiency.

B) cfDNA reference standard was spiked in TE buffer, followed by isolation with MiniMax Type S and a major alternative product. Bioanalyzer 2100 analysis demonstrated significantly higher cfDNA recovery rate of MiniMax Type S (red curve) compared to a major alternative product (blue curve).

Exhibit 3. Superior small DNA isolation efficiency.

C) Zoom in of B)in the region between 35–100 bp. MiniMax Type S (red curve) is compared to a major alternative product (blue curve). Bioanalyzer 2100 analysis demonstrated the efficient recovery at ~50 bp of MiniMax Type S (red curve), while a major alternative product (blue curve) failed.