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Apostle MiniGenomics Technology

 

Overview

Apostle MiniGenomics technology is a modified extension to our flagship Apostle MiniMax technology.  Apostle MiniGenomics focuses on providing an efficient and economic solution for isolating and purifying genomic nucleic acids from a spectrum of biological medium, supporting the accurate subsequent genetic and genomic analyses.

Empowered by the Apostle MiniGenomics technology, Apostle COVID-19 RNA Extraction System is composed of an Apostle MagTouch Nucleic Acids Isolation Automation System, an Apostle MiniGenomics Viral TotalNA Isolation Fast Kit, Apostle 96-Well Deep Well Plates and Tip Combs. The system is based on magnetic nanoparticle technologies designed for fast extraction and purification of viral nucleic acids from various kinds of biological samples collected in multiple transport media. To date, our clients have processed more than 10 million swabs in various CAP/CLIA clinical labs in the United States.  It's also included in a US FDA EUA authorized SARS-CoV-2 molecular diagnostic test: Fulgent COVID-19 by RT-PCT Test.

In addition, Apostle MiniGenomics High Efficiency Urinary Tract Microbiota DNA Isolation Kit is designed for isolation of microbial DNA from urine samples. The kit offers highly efficient, reproducible recovery of high-quality bacterial DNA with high yield. The isolated DNA samples are suitable for a broad range of subsequent applications, including sequencing, PCR, etc.

Apostle MiniGenomics technology can be utilized in a broad spectrum of nucleic acid isolation applications from a range of biological medium, offering accuracy, efficiency, and low cost.


Apostle MiniGenomics and MagTouch Technologies in COVID-19 Testing

Apostle COVID-19 RNA Extraction System Applied in the Effective Detection of SARS-CoV-2

Ed. Horner S. Application Note.

The current coronavirus disease 2019 (COVID-19) pandemic started in late 2019. COVID-19 is the result of severe acute respiratory syndrome 2 (SARS-CoV-2) virus contraction. COVID-19 is often accompanied by a wide range of symptoms including fever, cough, and shortness of breath. The SARS-CoV-2 virus consists of a ~30 kb RNA genome encoding for 15 proteins, including the spike protein that enables the virus to enter host cells. The current gold standard qualitative detection method, qRT-PCR, reverse transcribes the viral RNA into cDNA, which is subsequently amplified and quantitated.

This application note illustrates the effective detection of SARS-CoV-2 using the Apostle COVID-19 Viral RNA Isolation Automation System and qRT-PCR in clinical lab settings. This system uses efficient MiniGenomics magnetic nanoparticle technology for fast extraction and purification of viral nucleic acids from various types of biological samples collected in transport media. The proficient and consistent systems provide reliable test results to individuals that contribute to COVID-19 pandemic relief.

To date, our clients have processed more than 10 million swabs in various CAP/CLIA clinical labs in the United States. 

“Apostle COVID-19 RNA Extraction System is a fast and reliable solution for SARS-CoV-2 viral RNA extraction. We look forward to continuing the collaboration with Apostle and providing high quality COVID-19 tests for our community.” commented by Harry Gao, MD, PhD, DABMG, FACMG, Lab Director and Chief Scientific Officer of Fulgent Genetics.

Included in: FDA EUA Summary: Fulgent COVID-19 by RT-PCR TEST(FULGENT THERAPEUTICS).  For In vitro Diagnostic Use. Rx Only. For use under Emergency Use Authorization (EUA) only. US FDA. April 12, 2021. 

Apostle MiniGenomics Technology in Urinary Tract Microbiota DNA Isolation

The Apostle MiniGenomics High Efficiency Urinary Tract Microbiota DNA Isolation Kit is designed for isolation of microbial DNA from urine samples. The kit uses proprietary Apostle MiniGenomics technology, offers highly efficient, reproducible recovery of high-quality bacterial DNA with high yield. The isolated DNA samples are suitable for a broad range of subsequent applications, including sequencing, PCR, etc.

The protocol is designed for 96-well plate automated on Apostle MagTouch 2000 Automation Platform. Especially for samples with extreme low dilute bacteria concentration, centrifugal and concentration pretreatment could increase the total microbial DNA product.

For urine samples with broad range of bacteria concertration (from 10^6 to10^1 cfu/mL), Apostle MiniGenomics High Efficiency Urinary Tract Microbiota DNA Isolation Kit isolates microbial DNA with steady recovery and high efficiency, and no significant PCR inhibitors remain in the DNA product.