- Cancer is a genetically heterogeneous disease.
- Somatic mutations exist in both cancer and normal cells.
- We still know very little about the genetics of cancer. There is a lacking of a comprehensive and coherent way to mine the big data repository of cancer genetics and apply the applicable findings.
- The clinical application of liquid biopsy is further complicated by the characteristics of cell free tumor nucleic acids: low concentration, complex fragmentation, etc.
Here, we introduce Apostle Triton, a bioinformatics framework designed for liquid biopsy, which utilizes the big data from cancer genomics, evaluates disease effects of somatic mutations/variants and expression signatures, and apply the findings in the settings of liquid biopsy.