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Served over 20 million people since 2017 and counting

Why Apostle

Laboratory costs are high. Apostle supports our community with high-quality, cost-effective, and eco-friendly products:

  • Superior performance
  • Minimum 50% of savings on cost
  • Top-notch technical support
  • Environment-friendly / Save mother nature
  • Extensively validated and cited [Ref]

That’s why more and more research and clinical laboratories are now switching to Apostle technologies.
Best-in-class performance: cfDNA isolation

Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit

The ability to isolate and analyze circulating cell free DNA (cfDNA) at very low concentrations is becoming increasingly important, particularly in non-invasive prenatal test (NIPT), early cancer detection, and infectious disease diagnosis. Highly efficient isolation of cfDNA from complexed biological medium is a crucial step for subsequent cfDNA analysis. Apostle MiniMax technology offers a best-in-class efficiency and purity compared with conventional technologies to capture and isolate the circulating cell-free genetic materials. Its superb performance has been extensively validated.

As used by our clients in:
  • Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes. Cancer Cell 2024;42(2):225-237
  • A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results. Nature Medicine 2024; 30: 1013–1022
  • Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA. Nature Communications 2023;14:2017
  • Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection. Science Translational Medicine 2022;14:672
  • Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial. Nature Medicine 2022; 28:1022-1030
  • More ...
Superior performance: cfRNA isolation

Apostle MiniMax High Efficiency Cell-Free RNA Isolation Kit

Apostle MiniMax High Efficiency cfRNA Isolation Kit offers superior isolation efficiency of cell-free RNAs between 17 nt to 1000 nt, without phenol or chloroform. it is ready for a broad range of subsequent applications, including sequencing, PCR, etc. It is suitable for processing samples collected in various major blood collection tubes, especially which will prevent RNA degradation during storage.

As used by our clients in:
  • Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification. Nature Communications 15, Article number: 156 (2024).
  • Comprehensive characterization of small noncoding RNA profiles in hypoxia-induced pulmonary hypertension (HPH) rat tissues. iScience 2024 Feb 16; 27(2): 108815.
  • More ...
Superior performance: cfRNA isolation

Apostle MiniMax High Efficiency Total cfDNA/cfRNA (cfNAs) Isolation Kit

Apostle MiniMax cfDNA/cfRNA isolation kit is featured for its efficient recovery of cfDNA in the range between 50-3000bp and cfRNA in the range between 17-1000 nt, and the isolated nucleic acids can be applied for NGS and PCR-based downstream applications.
Features:
  • Superior isolation efficiency without using phenol or chloroform
  • Recovery of cfDNA /cfRNA in the one sample

As used by our clients in:
  • Liquid Biopsy for Evaluating Mutations and Chromosomal Aberrations in Cerebrospinal Fluid from Patients with Primary or Metastatic Central Tumors. The Journal of Liquid Biopsy (2024).
  • Combining cell-free RNA with cell-free DNA in liquid biopsy for hematologic and solid tumors. Heliyon 9 (2023) e16261; May 16, 2023.
  • More ...
Saving your operating cost

Apostle MiniMax Cell-Free DNA Blood Collection Tube

Powered by Apostle MiniMax technology, Apostle MiniMax cfDNA Blood Collection Tube (BCT) is an excellent tool for blood cfDNA preservation during blood collection, storage and transport.
This is achieved through Apostle MiniMax cfDNA BCT’s ability to:
  • Prevent the release and contamination of genomic DNA from cells in blood during storage and transportation.
  • Preserve existing cfDNA in blood from degradation.
  • Prevent existing cfDNA in blood from cross-linking with with other biomolecules (i.e. protein).
In summary, high cfDNA quality can be preserved with Apostle MiniMax cfDNA Blood Collection Tube for downstream applications, through the prevention of cfDNA degradation, crosslingking and contamination.

As used by our clients in:
Saving your operating cost

Apostle MiniGenomics Stool DNA Isolation Kit

Apostle MiniGenomics® Stool DNA Isolation Kit is designed for rapid extraction and purification of high-quality, ready-to-use genomic DNA and/or bacterial DNA from fresh or frozen stool samples.
  • Advanced magnetic nanoparticle technology for superior DNA adsorption and release
  • Standard purification methods suitable for biological samples in various forms or reagents
  • Specialized reagents to enhance DNA quality from challenging samples
  • Compatible with multiple high-throughput automated nucleic acid extraction platforms

As used by our clients in:
  • Intestinal microbiota as biomarkers for different colorectal lesions based on colorectal cancer screening participants in community. Front. Microbiol. 06 February 2025. Volume 16.
  • Combined detection of SDC2/ADHFE1/PPP2R5C methylation in stool DNA for colorectal cancer screening. Journal of Cancer Research and Clinical Oncology June 03, 2023.
  • A systematic evaluation of stool DNA preparation protocols for colorectal cancer screening via analysis of DNA methylation biomarkers. Clinical Chemistry and Laboratory Medicine 2021; 59(1): 91–99.
  • CE marked colon cancer test kits (as OEM supplier)
  • More ...
Next-generation Enrichment of Short DNA fragments for NIPT and Oncology Research

Apostle MiniEnrich Short Fragments Enrichment Kit

Precise DNA sizing can boost sequencing efficiency, reduce cost, improve data quality, and even allow sequencing of low-input samples, while current pervasive DNA sizing approaches are incapable of differentiating DNA fragments under 200 bp with high resolution (<20 bp). The Apostle MiniEnrich Short Fragments Enrichment Kit is a simple, automatable, high-resolution DNA size enrichment workflow on a magnetic nano-platform to exploit this 20 bp size difference and to enrich fetal DNA fragments from maternal blood.

As published in:
  • High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)
  • More ...
Next-generation purification, size selection, and long-read size selection

Apostle MiniEnrich Carboxyl Beads for Purification (AMPure XP alternative)

Next-generation purification, size selection, and long-read size selection.

The Apostle MiniEnrich Purification Beads is designed for purification and clean-up of DNA fragments from the contaminants in NGS and molecular biology workflows. It can be used on samples after DNA isolation, fragmentation, PCR amplification, cloning, library preparation, etc. With proprietary Apostle MiniEnrich technology, the kit is featured for its more efficient removal of contaminants and recovery of DNA fragments of interest than current market-leading products. This product is an effective alternative to AMPure XP, a brand name owned by Beckman Coulter. This product is not manufactured by Beckman Coulter.

As published in:
  • High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)
  • More ...
Served over 20 million people since 2017 and counting

MagTouch 2000

The MagTouch 2000 instrument is an automatic extraction and purification system for nucleic acids from various types of biological samples collected in multiple transport media, including extraction for cfDNA. It can absorb, transfer and release magnetic beads by a magnetic rod and magnetic rod sleeve to separate magnetic beads and samples. The operation is automatic, fast and simple.
Highlighted Features
  • Extremely robust and reliable; sustained 7x24 heavy use for 2+ years in very busy clinical laboratory environment. Notably, MagTouch 2000 has processed over 20 million samples during the COVID-19 pandemic, helping our community fight the global infectious disease.
  • Cost-effective; guaranteed 30% or more savings than other products
  • High-efficiency and high-throughput
  • Small footprint on the desktop
Publications and References
  • FDA document involving MagTouch 2000
  • As used by our clients in:
  • Rapid repeat infection of SARS-CoV-2 by two highly distinct delta-lineage viruses. Andrew J. Gorzalski , Christina Boyles, Victoria Sepcic, et al. Diagnostic Microbiology and Infectious Disease 2022; 104(1): 115747
  • Evaluation and integration of cell-free DNA signatures for detection of lung cancer. Cancer Letters Volume 604, 1 November 2024, 217216.
  • More ...
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High Quality, Cost Effective Lab Consumables

Costs of laboratory consumables can be high. Apostle serves our community with high-quality, cost-effective laboratory consumables. We are proud to be a supplier for many world-renowned universities and health centers including Stanford University, UCSF, UC Berkeley, University of Texas, etc.
  • Cell biology series
  • Molecular biology series
  • Liquid handling series
  • Sample collection and processing series
  • Comprehensive product line coverage with 900+SKU
  • High quality
  • Cost-effective. Guaranteed to save 30% cost or more.
Served over 20 million people since 2017 and counting

Haier Biomedical Lab Freezers, Energy Star (-30C, -86C)

Haier Biomedical Lab Freezers feature a built-in evaporator, large storage space, and adjustable shelfs, providing faster temperature pulldown, and a better temperature uniformity of set point +/- 3°C.
It is suitable for sample storage within blood banks, hospitals, disease control centres, research institutes, electronic, chemical and other industries, cryopreservation of plasma, biologics and other products, also suitable for cold tests for components and materials.
  • Energy-efficient Variable Frequency Inverter Technology
  • Large Capacity Storage with Excellent Temperature Uniformity
  • Low Noise
  • Environment Friendly
  • No. 1 best selling brand in Asia. Top 3 globally. Top quality.
Served over 20 million people since 2017 and counting

RiboCraft Alpha Transfection Reagent

RiboCraft Alpha Transfection Reagent is a one-of-a-kind transfection reagent, uniquely suited for both in vitro and in vivo RNA transfection. Coming from research results at Stanford University, this dual-function capability is a rare find in the market, offering unparalleled convenience and efficiency for researchers exploring the frontiers of genetic manipulation. RiboCraft Alpha provides any research program the unique ability to directly translate from cell-based assays to animal studies. RiboCraft Alpha stands out from the crowd with:
  • Dual-function capability: Efficiently delivers RNA both in vitro and in vivo
  • Versatility: Supports a wide range of RNA cargos, including mRNA, siRNA, and gene-editing tools
  • Robustness: Consistent and reliable performance across diverse cell lines and animal models

News

February 1, 2024

[Cancer Cell] Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability.  This new clinical study, led by scientists from MD Anderson Cancer Center and published in Cancer Cell (journal impact factor = 50.3), establishes that tumor and cfDNA methylation can be used to identify SCLC subtypes and might guide precision SCLC therapy.

Apostle Minimax cfDNA kit is one of the critical commercial assays listed in this article.    Congratulations to this clinical research team. To date, the Apostle Minimax technology has been used in 2 articles published in Nature Communications, 2 in Nature Medicine, 1 in Science Translational Medicine, 1 in PNAS, and over 60 scientific articles by over 60 international research and clinical teams in different journals.  

About Us

Apostle Inc is a biotechnology company in Pleasanton, CA, a provider of innovative technologies and services for public health and life sciences. Apostle develops and provides best-in-class nucleic acid isolation and preservation technologies, including innovative technologies in the space of liquid biopsy - the sampling and analysis of non-solid biological tissue, primarily blood, often utilizing circulating free DNA (cfDNA) as a biomarker. Apostle technologies have been applied in many world-class R&D studies, clinical laboratory settings, and public health response and surveillance. To date, over 20 million samples have been successfully processed using our technologies, and the number is quickly growing.